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导师简介

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吴长艾
发布时间：2021-09-30 浏览次数:383

个人简介

吴长艾，女，山东巨野人。2004年获得山东农业大学理学博士学位，至今在山东农业大学生命科学学院工作。生物化学与分子生物学国家级教学团队成员。“泰山学者”特聘岗位学术骨干。主要从事杂粮作物谷子及模式植物拟南芥耐盐碱、抗旱等重要基因的克隆、鉴定，探讨其调控机制及在作物遗传改良上的应用价值。近年来，承担国家重点研发计划子课题、转基因生物新品种培育科技重大专项、国家自然科学基金、山东省自然基金重大基础研究计划和山东省自然基金等课题8项。获得国家发明专利5项，山东省自然科学奖二等奖1项。在《Molecular Plant》、《RNA》、《Journal of Experimental Botany》和《作物学报》等国内外著名学术刊物上发表研究论文60余篇。

教育教学工作

承担本科生《基础生物化学》，《基础生物化学实验》；研究生 《基因工程原理与技术》、《基因表达调控》等课程的教学工作。

科学研究工作

 研究方向：

  1. 谷子、拟南芥盐、碱、干旱胁迫响应的基因挖掘与功能鉴定。

  2. 谷子盐、碱、干旱胁迫响应的激素调控机制。

  3. 盐、碱胁迫下谷子品质形成的分子机制。

科研简介：

科研项目

  1. 国家重点研发计划《杂粮作物抗逆和品质形成与调控》子课题《杂粮作物抗非生物逆境遗传机制与调控网络》子课题，2018.7-2022.12，主持

  2. 山东省自然科学基金重大基础研究项目《利用CRISPR/Cas9 基因组编辑技术创制玉米抗旱耐盐新种质》，2018.6-2020.12，主持

  3. 国家自然科学基金《棉花GhSAG基因的功能分析和分子机理研究》， 2015-2018，第二位

  4. 山东省自然科学基金《“棉花新型转录调节因子GhPLATZ1的功能和作用机理研究》，2015-2017，主持

  5.  973前期《玉米高温干旱抗性关键 microRNA基因的分离及功能鉴定》，2014-2016，第二位

  6. 国家自然科学基金《棉花盐诱导的4个海藻糖6-磷酸合酶和6个LEA基因的生理功能及其应用研究》2011-2013，主持

  7. 转基因生物新品种培育科技重大专项《棉花抗旱、耐盐和低温重要新基因的克隆和功能验证》2009-2012，主持

  8. 国家自然科学基金《五个拟南芥盐和干旱诱导的miRNAs的功能鉴定及调控途径研究》2010-2012，主持

  9. 国家自然科学基金《水稻干旱、盐胁迫相关microRNAs的分离和表达调控分析》2006-2008，主持

  10. 教育部“长江学者创新团队发展计划”《作物高产优质的生理与分子基础》2007-2009，子课题主持

  11. 山东农业大学博士基金《棉花Na+/H+逆向运转体基因的耐盐机理及其转基因耐盐棉花新种质的创造》2005-2007，主持

发表论文

  1. Lei Zhang#, Zipeng Yu#, Yang Xu, Miao Yu, Yue Ren, Shizhong Zhang, Guodong Yang, Jinguang Huang, Kang Yan, Chengchao Zheng*, Changai Wu*. Regulation of the stability and ABA import activity of NRT1.2/NPF4.6 by CEPR2-mediated phosphorylation in Arabidopsis. Molecular Plant, 2021, 14: 433-464.

  2. Lei Zhang#, Yue Ren#, Qian Xu, Yiman Wan, Shizhong Zhang, Guodong Yang, Jinguang Huang, Kang Yan, Chengchao Zheng*and Changai Wu*. SiCEP3, a C-terminally encoded peptide from Setaria italica, promotes ABA import and signaling. Journal of Experimental Botany.https://doi.org/10.1093/jxb/erab267.

  3. Shasha Liu, Rui Yang, Miao Liu, Shizhong Zhang, Kang Yan, Guodong Yang, Jinguang Huang, Chengchao Zheng*, Changai Wu*. PLATZ2 negatively regulates salt tolerance in Arabidopsis seedlings by directly suppressing the expression of the CBL4/SOS3 and CBL10/SCaBP8 genes. Journal of Experimental Botany, 2020, 71(18): 5589–5602.

  4. Zipeng Yu, Di Zhang, Yang Xu, Songsong Jin, Lei Zhang, Shizhong Zhang, Guodong Yang, Jinguang Huang, Kang Yan, Changai Wu*, Chengchao Zheng (2019) CEPR2 phosphorylates and accelerates the degradation of PYR/PYLs in Arabidopsis. Journal of Experimental Botany, 70 (19): 5457–5469.

  5. Zipeng Yu, Yang Xu, Lin Liu, Yarong Guo, Xisen Yuan, Xinyu Man, Chang Liu, Guodong Yang, Jinguang Huang, Kang Yan, Chengchao Zheng, Changai Wu,* and Shizhong Zhang* (2019) The Importance of Conserved Serine for C-Terminally Encoded Peptides Function Exertion in Apple. International Journal of Molecular Sciences, 20: 775.

  6. Shicai Zhang, Rui Yang, Yanqing Huo, Shasha Liu, Guodong Yang, Jinguang Huang, Chengchao Zheng, Changai Wu* (2018) Expression of cotton PLATZ1 in transgenic Arabidopsis reduces sensitivity to osmotic and salt stress for germination and seedling establishment associated with modification of the abscisic acid, gibberellin, and ethylene signaling pathways. BMC Plant Biology, 18: 218

  7. Yumeng Chen, Yan Wang, Jinguang Huang, Chengchao Zheng, Congxi Cai, Qiaomei Wang, Changai Wu* (2017) Salt and methyl jasmonate aggravate growth inhibition and senescence in Arabidopsis seedlings via the JA signaling pathway. Plant Science 261: 1-9.

  8. Caili Wang, Shicai Zhang, Shengdong Qi, Chengchao Zheng, Changai Wu* (2016) Delayed germination of Arabidopsis seeds under chilling stress by overexpressing an abiotic stress inducible GhTPS11. GENE, 575: 206-212.

  9. Changtian Chen, Changai Wu1, Jiaming Miao, Yunxue Lei, Dongxiao Zhao, Dan Sun, Guodong Yang, Jinguang Huang and Chengchao Zheng. (2014) Arabidopsis SAG protein containing the MDN1 domain participates in seed germination and seedling development by negatively regulating ABI3 and ABI5. Journal of Experimental Botany, 65(1): 35-45.

  10. Nana Ma, Hailong Feng, Xia Meng, Dong Li, Dongyue Yang,Changai Wu*,  Qingwei Meng*. (2014)Overexpression of tomato SlNAC1 transcription factor alters fruit pigmentation and softening. BMC Plant Biology, 14:351.

  11. Yunxue Lei, Yaru Fu, Changtian Chen, Jinguang Huang, Changai Wu*. (2014) Overexpression of Arabidopsis wali7 domain-containing protein ASR produces auxin-mediated short-root phenotype.Journal of Plant Growth Regulation, 33:355-363.

  12. Yanjie Li, Yi Fang, Yaru Fu, Jinguang Huang, Changai Wu*, Chengchao Zheng*. (2013) NFYA1 is involved in regulation of postgermination growth arrest under salt stress in Arabidopsis. PLoS One, 8(4): e61289.  

  13. Peng Liu, Kang Yan, YunXue Lei, Rui Xu, YueMin Zhang, Guodong Yang, Jinguang Huang, Changai Wu*, Chengchao Zheng*. (2013) Transcript profiling of microRNAs during the early development of the maize brace root via Solexa sequencing. Genomics, 101: 149-156

  14. Kang Yan, Peng Liu, Chang-Ai Wu, Guo-Dong Yang, Rui Xu, Qian-Huan Guo, Jin-Guang Huang, and Cheng-Chao Zheng. (2012) Stress-Induced Alternative Splicing Provides a Mechanism for the Regulation of MicroRNA Processing in Arabidopsis thaliana. Molecular Cell, 48: 521-531.

  15. Wei Lu, Xiaoli Tang, Yanqing Huo, Rui Xu, Shengdong Qi, Jingguang Huang, Chengchao Zheng, Changai Wu*. (2012) Identification and characterization of fructose 1,6-bisphosphate aldolase genes in Arabidopsis reveals a gene family with diverse responses to abiotic stresses. Gene, 503: 65-74.

  16. Gang Wang, Qingguo Zhu, Qingwei Meng, Changai Wu*. (2012) Transcript profiling during salt stress of young cotton (Gossypium hirsutum) seedlings via Solexa sequencing. Acta Physiologiae Plantarum, 34:107-115.

  17. Yanjie Li, Yaru Fu, Jingguang Huang, Changai Wu*, Chengchao Zheng*. (2011) Transcript profiling during the early development of the maize brace root via Solexa sequencing. The FEBS Journal, 278: 156-166.

  18. Ruirui Xu, Shengdong Qi, Longtao Lu, Changtian Chen, Changai Wu*, Chengchao Zheng*. (2011) A DExD/H box RNA helicase is important for potassium deprivation responses and tolerance in Arabidopsis thaliana. The FEBS Journal, 278(13): 2293-2306.

  19. Jing Shi, Liang Zhang, Hailong An, Changai Wu*, Xingqing Guo*. (2011) GhMPK16, a novel stress-responsive group D MAPK gene from cotton, is involved in disease resistance and drought sensitivity. BMC Molecular Biology, 12:22.

  20. Yanjie Li, Yaru Fu, Lusha Ji, Changai Wu*, Chengchao Zheng*. (2010). Characterization and expression analysis of the Arabidopsis mir169 family. Plant Science, 178: 271-280.

  21. Pei Liu, Guodong Yang, Hong Li, Changai Wu*. (2010) Overexpression of NHX1s in transgenic Arabidopsis enhances photoprotection capacity in high salinity and drought conditions. Acta Physiologiae Plantarum, 32: 81-90.

  22. Hanhua Liu, Xin Tian, Yanjie Li, Changai Wu*, Chengchao Zheng*. (2008) Microarray-based Analysis of Stress-regulated microRNAs in Arabidopsis thaliana. RNA, 14: 836-843.

  23. Changai Wu1, Guodong Yang, Qingwei Meng, Chengchao Zheng. (2004) The cotton GhNHX1 gene encoding a novel putative tonoplast Na+/H+ antiporter plays an important role in salt stress. Plant & Cell Physiology, 45: 600-607. 

获得专利

  1. 芹菜素在制备促进植物生长、提高植物耐盐性的制剂中的应用，专利号：ZL 2020 1 0854231.4

  2. 棉花Na+/H+反向转运蛋白基因及其应用，专利号：ZL02151530.1

  3. 棉花金属硫蛋白基因GhMT1序列及其克隆与应用，专利号：ZL 2005 1 0104301.X

  4. 一种棉花促分裂原蛋白激酶基因GhMAPK6及其应用，专利号：ZL 2010 1 0590833.X

  5. 一种可提高转基因作物细菌抗性的基因GhMKK5及其应用，ZL 2010 1 0590843.X

联系方式

通讯地址：山东省泰安市岱宗大街61号

联系电话:  0538-8249303      

E-mail: cawu@sdau.edu.cn

联系地址：山东农业大学岱宗校区国重楼  618